Caging and COM-Bating Antibiotic Resistance

Jason W Rosch; Elaine I Tuomanen

doi:10.1016/j.chom.2020.03.013

Caging and COM-Bating Antibiotic Resistance

Cell Host Microbe. 2020 Apr 8;27(4):489-490. doi: 10.1016/j.chom.2020.03.013.

Authors

Jason W Rosch¹, Elaine I Tuomanen²

Affiliations

¹ Department of Infectious Diseases, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
² Department of Infectious Diseases, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address: elaine.tuomanen@stjude.org.

PMID: 32272070
DOI: 10.1016/j.chom.2020.03.013

Abstract

Horizontal gene transfer (HGT) facilitates spead of antibiotic resistance elements. In this issue of Cell Host & Microbe, Domenech et al. discover that compounds disrupting proton motive force block natural competence (COM) and interrupt intraspecies HGT and exchange of antibiotic resistance. Such strategies might minimize clinical spread of antibiotic resistance.

Publication types

Comment

MeSH terms

Bacteria / genetics
Drug Resistance, Microbial
Gene Transfer, Horizontal*
Plasmids
Proton-Motive Force*