Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates

Chia-Han Chiang; Sang Min Won; Amy L Orsborn; Ki Jun Yu; Michael Trumpis; Brinnae Bent; Charles Wang; Yeguang Xue; Seunghwan Min; Virginia Woods; Chunxiu Yu; Bong Hoon Kim; Sung Bong Kim; Rizwan Huq; Jinghua Li; Kyung Jin Seo; Flavia Vitale; Andrew Richardson; Hui Fang; Yonggang Huang; Kenneth Shepard; Bijan Pesaran; John A Rogers; Jonathan Viventi

doi:10.1126/scitranslmed.aay4682

Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates

Sci Transl Med. 2020 Apr 8;12(538):eaay4682. doi: 10.1126/scitranslmed.aay4682.

Authors

Chia-Han Chiang¹, Sang Min Won², Amy L Orsborn^{3

4

5}, Ki Jun Yu⁶, Michael Trumpis⁷, Brinnae Bent⁷, Charles Wang⁷, Yeguang Xue^{8

9}, Seunghwan Min¹⁰, Virginia Woods⁷, Chunxiu Yu^{7

11}, Bong Hoon Kim^{12

13}, Sung Bong Kim¹⁴, Rizwan Huq¹⁵, Jinghua Li^{14

16

17}, Kyung Jin Seo¹⁸, Flavia Vitale^{19

20}, Andrew Richardson²¹, Hui Fang¹⁸, Yonggang Huang^{8

9

14

22}, Kenneth Shepard^{15

23}, Bijan Pesaran^{24

25}, John A Rogers^{26

9

14

16

22

27

28

29

30}, Jonathan Viventi^{1

31

32}

Affiliations

¹ Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. j.viventi@duke.edu jrogers@northwestern.edu bijan@nyu.edu kenchiangch@gmail.com.
² Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
³ Center for Neural Science, New York University, New York, NY 10003, USA.
⁴ Department of Electrical and Computer Engineering, University of Washington, Seattle, WA 98195, USA.
⁵ Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
⁶ School of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, Republic of Korea.
⁷ Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
⁸ Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.
⁹ Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.
¹⁰ Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.
¹¹ Department of Biological Science, Michigan Technological University, Houghton, MI 49931, USA.
¹² Department of Organic Materials and Fiber Engineering, Soongsil University, Seoul 06978, Republic of Korea.
¹³ Department of Information Communication, Materials, and Chemistry Convergence Technology, Soongsil University, Seoul 06978, Republic of Korea.
¹⁴ Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
¹⁵ Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.
¹⁶ Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
¹⁷ Department of Materials Science and Engineering, Center for Chronic Brain Injury, The Ohio State University, Columbus, OH 43210, USA.
¹⁸ Department of Electrical and Computer Engineering, Northeastern University, Boston, MA 02115, USA.
¹⁹ Department of Neurology, Department of Bioengineering, Department of Physical Medicine & Rehabilitation, Center for Neuroengineering and Therapeutics, University of Pennsylvania, PA 19104, USA.
²⁰ Center of Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.
²¹ Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA.
²² Center for Bio-integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
²³ Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
²⁴ Center for Neural Science, New York University, New York, NY 10003, USA. j.viventi@duke.edu jrogers@northwestern.edu bijan@nyu.edu kenchiangch@gmail.com.
²⁵ Department of Neurology, NYU Langone Health, New York, NY 10016, USA.
²⁶ Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA. j.viventi@duke.edu jrogers@northwestern.edu bijan@nyu.edu kenchiangch@gmail.com.
²⁷ Simpson Querrey Institute, Northwestern University, Chicago, IL 60611, USA.
²⁸ Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
²⁹ Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
³⁰ Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
³¹ Department of Neurobiology, Duke University, Durham, NC 27708, USA.
³² Department of Neurosurgery, Duke University, Durham, NC 27708, USA.

Abstract

Long-lasting, high-resolution neural interfaces that are ultrathin and flexible are essential for precise brain mapping and high-performance neuroprosthetic systems. Scaling to sample thousands of sites across large brain regions requires integrating powered electronics to multiplex many electrodes to a few external wires. However, existing multiplexed electrode arrays rely on encapsulation strategies that have limited implant lifetimes. Here, we developed a flexible, multiplexed electrode array, called "Neural Matrix," that provides stable in vivo neural recordings in rodents and nonhuman primates. Neural Matrix lasts over a year and samples a centimeter-scale brain region using over a thousand channels. The long-lasting encapsulation (projected to last at least 6 years), scalable device design, and iterative in vivo optimization described here are essential components to overcoming current hurdles facing next-generation neural technologies.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Brain
Brain Mapping*
Electrodes, Implanted
Microelectrodes
Primates
Rodentia*

Grants and funding

U01 NS099697/NS/NINDS NIH HHS/United States