Objective: To investigate the effect of the artificial facial nerve on the restoration of orbicularis oculi muscle function for unilateral peripheral facial paralysis in rabbit. Methods: Artificial facial nerve was implanted into the rabbit with unilateral peripheral facial paralysis between January 2018 and May 2019. At different time points after operation, the affected orbicularis oculi muscles' stimulation closure threshold and the synchronism about the motion of the two sides of orbicularis oculi muscles were monitored. T test was used with SPSS 13.0 software. Results: There was no significant difference in the closure threshold of the orbicularis oculi muscle on the 7th and 28th days after artificial facial nerve implantation (P>0.05). The synchronism of the normal side eye closing movement triggered the affected orbicular oculi muscle movement with the artificial facial nerve was up 19/20 to 20/20 at different times. Conclusions: The artificial facial nerve system had the features of stable working condition and high synchronizing effect for stimulating movement. It could restore the closed eye function in animals with peripheral facial paralysis animals and had great clinical application prospects.
目的： 探讨全植入人工面神经恢复周围性面神经麻痹兔眼轮匝肌闭眼功能的效果。 方法： 2018年1月至2019年5月，将人工面神经植入单侧周围性面神经麻痹兔体内，于术后第7、28天，监测患侧眼轮匝肌刺激闭合阈及患侧与健侧眼轮匝肌运动的同步性，并通过SPSS13.0软件进行t检验。 结果： 人工面神经植入术后第7、28天，实验兔患侧眼轮匝肌的闭合阈差异无统计学意义（P值均>0.05）。在观察期间，刺激健侧眼睑20次诱发健侧闭眼，未发现健侧未动而患侧运动的情况；植入第7天和第28天，患侧与健侧同步运动的同步率在19/20~20/20，差异均无统计学意义（P值均>0.05）。 结论： 人工面神经系统具备工作状态稳定、刺激运动效果同步性高的特点，能够较好地恢复周围性面神经麻痹动物的眼轮匝肌的闭眼功能。.
Keywords: Facial nerve; Facial paralysis; Implant electric stimulator.