Breaking the Enigma Code of Angiotensin II Type 2 Receptor Signaling

Anastasiia Sadybekov; Vsevolod Katritch

doi:10.1016/j.str.2020.03.004

Breaking the Enigma Code of Angiotensin II Type 2 Receptor Signaling

Structure. 2020 Apr 7;28(4):390-392. doi: 10.1016/j.str.2020.03.004.

Authors

Anastasiia Sadybekov¹, Vsevolod Katritch²

Affiliations

¹ Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.
² Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA; Department of Quantitative and Computational Biology, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: katritch@usc.edu.

Abstract

In this issue of Structure, Asada et al. (2019) present angiotensin receptor AT₂R structure in complex with its main endogenous agonist, AngII peptide. Complementing the previous structural studies, the new complex structure sheds light on the AT₂R activation mechanism and opens new avenues for drug discovery targeting this enigmatic receptor.

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MeSH terms

Angiotensin II
Peptide Hormones*
Protein Transport
Receptor, Angiotensin, Type 2*
Signal Transduction

Substances

Peptide Hormones
Receptor, Angiotensin, Type 2
Angiotensin II