The Emerging Roles of NDR1/2 in Infection and Inflammation

Xiaolan Ye; Naomi Ong; Huazhang An; Yuejuan Zheng

doi:10.3389/fimmu.2020.00534

The Emerging Roles of NDR1/2 in Infection and Inflammation

Front Immunol. 2020 Mar 24:11:534. doi: 10.3389/fimmu.2020.00534. eCollection 2020.

Authors

Xiaolan Ye¹, Naomi Ong¹, Huazhang An², Yuejuan Zheng¹

Affiliations

¹ Center for Traditional Chinese Medicine and Immunology Research, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² Center for Translational Medicine, Clinical Cancer Institute, Second Military Medical University, Shanghai, China.

Abstract

The nuclear Dbf2-related (NDR) kinases NDR1 and NDR2 belong to the NDR/LATS (large tumor suppressor) subfamily in the Hippo signaling pathway. They are highly conserved from yeast to humans. It is well-known that NDR1/2 control important cellular processes, such as morphological changes, centrosome duplication, cell proliferation, and apoptosis. Recent studies revealed that NDR1/2 also play important roles in the regulation of infection and inflammation. In this review, we summarized the roles of NDR1/2 in the modulation of inflammation induced by cytokines and innate immune response against the infection of bacteria and viruses, emphasizing on how NDR1/2 regulate signaling transduction through Hippo pathway-dependent and -independent manners.

Keywords: Hippo signaling pathway; NDR1; NDR2; infection; inflammation; innate immunity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Immunity, Innate / immunology*
Infections / immunology*
Inflammation / immunology*
Protein Serine-Threonine Kinases / immunology*

Substances

Protein Serine-Threonine Kinases