Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics

Ji Hoon Yu; Chun Young Im; Sang-Hyun Min

doi:10.3389/fcell.2020.00120

Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics

Front Cell Dev Biol. 2020 Mar 17:8:120. doi: 10.3389/fcell.2020.00120. eCollection 2020.

Authors

Ji Hoon Yu¹, Chun Young Im¹, Sang-Hyun Min¹

Affiliation

¹ New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, South Korea.

Abstract

Peptidyl-prolyl isomerase (PIN1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which results in the alteration of protein structure, function, and stability. The altered structure and function of these phosphorylated proteins regulated by PIN1 are closely related to cancer development. PIN1 is highly expressed in human cancers and promotes cancer as well as cancer stem cells by breaking the balance of oncogenes and tumor suppressors. In this review, we discuss the roles of PIN1 in cancer and PIN1-targeted small-molecule compounds.

Keywords: PIN1; PIN1 inhibitor; cancer therapeutics; proline-directed phosphorylation; prolyl isomerase; tumorigenesis.

Publication types

Review