Non-Nodal CD5-Negative Mantle Cell Lymphoma with Secondary TP53 Deletion

Robert K McCall; Changlee S Pang; Mark J Pettenati

doi:10.1155/2020/9185432

Non-Nodal CD5-Negative Mantle Cell Lymphoma with Secondary TP53 Deletion

Case Rep Hematol. 2020 Mar 18:2020:9185432. doi: 10.1155/2020/9185432. eCollection 2020.

Authors

Robert K McCall¹, Changlee S Pang², Mark J Pettenati³

Affiliations

¹ Molecular Pathology Laboratory Network, Maryville, TN, USA.
² University of Colorado School of Medicine, Aurora, CO, USA.
³ Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.

Abstract

Mantle cell lymphoma is a non-Hodgkin lymphoproliferative neoplasm with several clinical and morphologic variants linked, primarily, through genetic derangement of the cyclin D1 locus. Aberrant phenotypes have been described, though prognostic data in such cohorts are limited due to a paucity of cases. We report a case of mantle cell lymphoma with non-nodal clinical presentation, aberrant loss of CD5 expression, and concomitant cytogenetic deletion of 17p. While non-nodal disease is often associated with an improved prognosis in mantle cell lymphoma, this 67-year-old patient experienced a more challenging clinical course with a poor initial response to chemotherapy. Therefore, this case may represent a type of non-nodal mantle cell lymphoma with a prognosis similar to that of classical cases due to the additional phenotypic and genetic alterations found in this patient.

Publication types

Case Reports