Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form

Ibtissem Ben Nacef; Sabrine Mekni; Chedi Mhedhebi; Ines Riahi; Imen Rojbi; Mchirgui Nadia; Karima Khiari

doi:10.1155/2020/6284764

Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form

Case Rep Endocrinol. 2020 Mar 17:2020:6284764. doi: 10.1155/2020/6284764. eCollection 2020.

Authors

Ibtissem Ben Nacef¹, Sabrine Mekni¹, Chedi Mhedhebi¹, Ines Riahi², Imen Rojbi¹, Mchirgui Nadia¹, Karima Khiari¹

Affiliations

¹ Department of Endocrinology, Charles Nicolle Hospital, Tunis, Tunisia.
² Department of Otorhinolaryngology-Head and Neck Surgery, Charles Nicolle Hospital, Tunis, Tunisia.

Abstract

Langerhans cell histiocytosis (LCH) is a rare sporadic proliferative disorder of Langerhans cells. LCH rarely involves the thyroid gland. We report herein a case of a disseminated chronic form of LCH with a diagnosis established by histological examination of the thyroid gland. It is about a 37-year-old female who underwent total thyroidectomy for a thyroid nodule of the right lobe. Histological study showed a granulomatous thyroiditis, and the immunohistochemistry study revealed a strong positivity of histiocytes for the CD1 antigen and for the S100 protein. The incidence of LCH involving the thyroid gland, either as an isolated lesion or as a part of multisystemic disease, is extremely rare.

Publication types

Case Reports