The Challenge of Hemorrhagic Shock Management During Low-Molecular-Weight Heparin Treatment

Alessandro Morotti; Enrica Branca; Angelo Guerrasio

doi:10.2147/JBM.S232109

The Challenge of Hemorrhagic Shock Management During Low-Molecular-Weight Heparin Treatment

J Blood Med. 2020 Mar 19:11:103-105. doi: 10.2147/JBM.S232109. eCollection 2020.

Authors

Alessandro Morotti¹, Enrica Branca¹, Angelo Guerrasio¹

Affiliation

¹ Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.

Abstract

The reversal of low-molecular-weight heparin (LMWH) and the management of bleeding patients on LMWH remain highly challenging. Even if LMWH is very extensively administered in the prophylaxis and treatment of venous thrombosis, specific antidotes are lacking, and reversal strategies have very weak grade of evidences on clinical effectiveness. We here describe a reversal strategy with protamine and FVIIa in a patient presenting with hemorrhagic shock and cardiocirculatory arrest.

Keywords: FVIIa; LMWH bleeding; LMWH reversal; mantle lymphoma; protamine.

Publication types

Case Reports