NIR fluorescent organic nanoparticles for photoinduced nitric oxide delivery with self monitoring and real time reporting abilities

Krishna Kalyani Behara; Y Rajesh; Amrita Chaudhuri; Moumita Gangopadhyay; Mahitosh Mandal; N D Pradeep Singh

doi:10.1039/c8tb01209a

NIR fluorescent organic nanoparticles for photoinduced nitric oxide delivery with self monitoring and real time reporting abilities

J Mater Chem B. 2018 Oct 14;6(38):6042-6046. doi: 10.1039/c8tb01209a. Epub 2018 Sep 17.

Authors

Krishna Kalyani Behara¹, Y Rajesh, Amrita Chaudhuri, Moumita Gangopadhyay, Mahitosh Mandal, N D Pradeep Singh

Affiliation

¹ Department of Chemistry, Indian Institute of Technology (IIT) Kharagpur, Kharagpur-721302, India. ndpradeep@chem.iitkgp.ernet.in.

PMID: 32254814
DOI: 10.1039/c8tb01209a

Abstract

Nitric oxide photodonor (NOD) conjugated perylene tetracarboxylate ester (TPT) based fluorescent organic TPT(NOD)₄ nanoparticles (NPs) with aggregation induced NIR emission have shown photoinduced nitric oxide delivery along with a red to green emission transition. Time dependent imaging and dose dependent cytotoxicity studies of these NPs using U87MG cells demonstrate the self monitoring and real time reporting abilities and potential anticancer activity of the system, respectively.