A single-step multi-level supramolecular system for cancer sonotheranostics

Huirong Lin; Shuang Li; Junqing Wang; Chengchao Chu; Yang Zhang; Xin Pang; Peng Lv; Xiaoyong Wang; Qingliang Zhao; Junjie Chen; Hongmin Chen; Wen Liu; Xiaoyuan Chen; Gang Liu

doi:10.1039/c8nh00276b

A single-step multi-level supramolecular system for cancer sonotheranostics

Nanoscale Horiz. 2019 Jan 1;4(1):190-195. doi: 10.1039/c8nh00276b. Epub 2018 Oct 15.

Authors

Huirong Lin¹, Shuang Li, Junqing Wang, Chengchao Chu, Yang Zhang, Xin Pang, Peng Lv, Xiaoyong Wang, Qingliang Zhao, Junjie Chen, Hongmin Chen, Wen Liu, Xiaoyuan Chen, Gang Liu

Affiliation

¹ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102, China. gangliu.cmitm@xmu.edu.cn.

PMID: 32254155
DOI: 10.1039/c8nh00276b

Abstract

A multi-level supramolecular system produced by single-step Fe³⁺-mediated ionic crosslinking self-assembly can overcome the critical issues of current sonodynamic therapy (SDT) and address the need to monitor therapeutic effects in vivo with a non-invasive approach. This rational design of organic sonosensitizer-based formulation shows great potential for clinical SDT against deep-seated cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / therapeutic use*
Cell Line, Tumor
Humans
Indocyanine Green / chemistry
Indocyanine Green / therapeutic use*
Iron / chemistry
Mice
Microbubbles / therapeutic use*
Neoplasms / drug therapy*
Theranostic Nanomedicine / methods*
Ultrasonic Therapy / methods*

Substances

Antineoplastic Agents
Iron
Indocyanine Green