Whether cell death caused by T lymphocytes and natural killer (NK) cells would be immunogenic per se has been a matter of intense debate. Two back-to-back papers from the Melero's and Pardo's groups have now resolved this conundrum, demonstrating that T and NK cell-mediated cytotoxicity represents indeed a bona fide variant of immunogenic cell death.
Keywords: CD8-Positive T-Lymphocytes; cytotoxicity, immunologic; natural killer T-cells; receptors, chimeric antigen.
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