Increased Risk of Polycystic Ovary Syndrome and It's Comorbidities in Women with Autoimmune Thyroid Disease

Chun-Wei Ho; Hsin-Hung Chen; Ming-Chia Hsieh; Ching-Chu Chen; Sheng-Pang Hsu; Hei-Tung Yip; Chia-Hung Kao

doi:10.3390/ijerph17072422

Increased Risk of Polycystic Ovary Syndrome and It's Comorbidities in Women with Autoimmune Thyroid Disease

Int J Environ Res Public Health. 2020 Apr 2;17(7):2422. doi: 10.3390/ijerph17072422.

Authors

Chun-Wei Ho¹, Hsin-Hung Chen^{1

2}, Ming-Chia Hsieh^{1

3

4}, Ching-Chu Chen^{5

6}, Sheng-Pang Hsu⁵, Hei-Tung Yip^{7

8}, Chia-Hung Kao^{9

10

11

12}

Affiliations

¹ Intelligent Diabetes Metabolism and Exercise Center, China Medical University Hospital, Taichung 40447 Taiwan.
² School of Medicine, Institute of Medicine and Public Health, Chung Shan Medical University, Taichung 40201, Taiwan.
³ Division of Clinical Nutrition, China Medical University Hospital, Taichung 40447, Taiwan.
⁴ Graduate Institute of Integrative Medicine, China Medical University, Taichung 40447, Taiwan.
⁵ Division of Endocrinology and Metabolism, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan.
⁶ School of Chinese Medicine, China Medical University, Taichung 40447, Taiwan.
⁷ Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan.
⁸ College of Medicine, China Medical University, Taichung 40447, Taiwan.
⁹ Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung 40447, Taiwan.
¹⁰ Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung 40447, Taiwan.
¹¹ Department of Bioinformatics and Medical Engineering, Asia University, Taichung 40447, Taiwan.
¹² Center of Augmented Intelligence in Healthcare, China Medical University Hospital, Taichung 40447, Taiwan.

Abstract

Objective: To investigate the prevalence of polycystic ovary syndrome (PCOS) and its comorbidities in patients with autoimmune thyroid disease (AITD).

Population: In this cohort study, patients newly diagnosed as having Hashimoto thyroiditis (HT) or Grave disease (GD) were recruited into the AITD group.

Method: The logistic regression model was used to investigate the association between exposure, endpoint, later diseases and treatment.

Main outcome measures: We assessed the cumulative incidence using the Kaplan-Meier method and verified the difference by the log-rank test.

Results: The AITD group included 3599 GD patients and 1332 HT patients. PCOS risk in patients with AITD was higher than that in the control group (adjusted hazard ratio = 1.39; 95% confidence interval = 1.07-1.71). In patients with both AITD and PCOS, the odds ratios of diabetes, hyperlipidemia and coronary artery disease were 2.48, 2.05 and 2.63, respectively.

Conclusions: The risks of PCOS and its comorbidities such as diabetes, dyslipidemia and cardiac artery disease are high in patients with AITD in Taiwan.

Keywords: autoimmune thyroid disease (AITD); grave disease (GD); hashimoto thyroiditis (HT); polycystic ovary syndrome (PCOS).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cohort Studies
Comorbidity
Female
Graves Disease* / complications
Hashimoto Disease* / complications
Humans
Middle Aged
Polycystic Ovary Syndrome* / epidemiology
Taiwan