Identification of a novel fusion gene, TRIM52-RACK1, in oral squamous cell carcinoma

Mol Cell Probes. 2020 Aug:52:101568. doi: 10.1016/j.mcp.2020.101568. Epub 2020 Apr 3.

Abstract

Gene fusion is caused by the linkage of previously separate genes or sequences. Recently, an increasing number of novel fusion genes have been identified and associated with tumor progression, and several of them have been suggested as promising targets for tumor therapy. However, there are hardly any studies reporting the association of fusion genes with the progression of oral squamous cell carcinoma (OSCC). In this study, we identified a total of 11 fused genes in OSCC cells. We further analyzed the structure of one fused gene, TRIM52-RACK1, and detected its function in tumor progression in vitro. We found that TRIM52-RACK1 was caused by a deletion of 181,257,187-181,247,386 at 5q35.3 and it promoted OSCC cell proliferation, migration, and invasion. Therefore, TRIM52-RACK1 can be a promising target for tumor therapy in OSCC.

Keywords: Fused gene; Oral squamous cell carcinoma; RACK1; TRIM52; TRIM52-RACK1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Squamous Cell / genetics*
  • Cell Line, Tumor
  • Cell Movement / genetics
  • Cell Proliferation / genetics
  • Humans
  • Mouth Neoplasms / genetics*
  • Neoplasm Invasiveness
  • Oncogene Proteins, Fusion / genetics*
  • Oncogene Proteins, Fusion / metabolism

Substances

  • Oncogene Proteins, Fusion
  • TRIM52-RACK1 oncogenic fusion protein, human