The overview and prospects of BNCT facility at Tsing Hua Open-pool reactor

Shiang-Huei Jiang; Yen-Wan Hsueh Liu; Fong-In Chou; Hong-Ming Liu; Jinn-Jer Peir; Yuan-Hao Liu; Yu-Shiang Huang; Ling-Wei Wang; Yi-Wei Chen; Sang-Hue Yen; Yuan-Hung Wu; Ching-Sheng Liu; Jia-Cheng Lee; Chi-Wei Chang; Shyh-Jen Wang; Wen-Sheng Huang; Ji-Jung Kai

doi:10.1016/j.apradiso.2020.109143

The overview and prospects of BNCT facility at Tsing Hua Open-pool reactor

Appl Radiat Isot. 2020 Jul:161:109143. doi: 10.1016/j.apradiso.2020.109143. Epub 2020 Mar 24.

Authors

Shiang-Huei Jiang¹, Yen-Wan Hsueh Liu², Fong-In Chou³, Hong-Ming Liu⁴, Jinn-Jer Peir⁴, Yuan-Hao Liu⁴, Yu-Shiang Huang³, Ling-Wei Wang⁵, Yi-Wei Chen⁵, Sang-Hue Yen⁵, Yuan-Hung Wu⁵, Ching-Sheng Liu⁵, Jia-Cheng Lee⁵, Chi-Wei Chang⁶, Shyh-Jen Wang⁶, Wen-Sheng Huang⁶, Ji-Jung Kai⁴

Affiliations

¹ Institute of Nuclear Engineering and Science, National Tsing Hua University, Taiwan, ROC. Electronic address: shjiang@mx.nthu.edu.tw.
² Institute of Nuclear Engineering and Science, National Tsing Hua University, Taiwan, ROC.
³ Institute of Nuclear Engineering and Science, National Tsing Hua University, Taiwan, ROC; Nuclear Science and Technology Development Center, National Tsing Hua University, Taiwan, ROC.
⁴ Nuclear Science and Technology Development Center, National Tsing Hua University, Taiwan, ROC.
⁵ Department of Oncology, Taipei Veterans General Hospital, Taiwan, ROC.
⁶ Department of Nuclear Medicine, Taipei Veterans General Hospital, Taiwan, ROC.

PMID: 32250842
DOI: 10.1016/j.apradiso.2020.109143

Abstract

The whole picture of the BNCT facility at Tsing Hua Open-pool Reactor will be presented which consists of the following aspects: the construction project, the beam quality, routine operations including the QA program for the beam delivery, determination of boron-10 concentration in blood, T/N ratio, and the clinical affairs including the patient recruit procedure and the patient irradiation procedure. The facility is positioned to serve for conducting clinical trials, emergent (compassionate) treatments, and R&D works.

Keywords: BNCT facility; Overview; Prospects; THOR.

MeSH terms

Boron Neutron Capture Therapy*
China
Facility Design and Construction
Humans
Neoplasms / radiotherapy*
Nuclear Reactors*
Phantoms, Imaging
Radiotherapy Planning, Computer-Assisted / methods
Remission Induction
Survival Rate