Velucarpin D, a new pterocarpan from the stems of Dalbergia velutina and its cytotoxicity

Sutin Kaennakam; Edwin Risky Sukandar; Siriwat Hongnak; Kitiya Rassamee; Pongpun Siripong; Santi Tip-Pyang

doi:10.1080/14786419.2020.1749613

Velucarpin D, a new pterocarpan from the stems of Dalbergia velutina and its cytotoxicity

Nat Prod Res. 2021 Nov;35(21):3925-3930. doi: 10.1080/14786419.2020.1749613. Epub 2020 Apr 5.

Authors

Sutin Kaennakam^{1

2}, Edwin Risky Sukandar¹, Siriwat Hongnak¹, Kitiya Rassamee³, Pongpun Siripong³, Santi Tip-Pyang¹

Affiliations

¹ Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
² Department of Agro-Industrial, Food, and Environmental Technology, Faculty of Applied Science, King Mongkut's University of Technology North Bangkok (KMUTNB), Bangkok, Thailand.
³ Natural Products Research Section, Research Division, National Cancer Institute, Bangkok, Thailand.

PMID: 32249600
DOI: 10.1080/14786419.2020.1749613

Abstract

A new pterocarpan, named velucarpin D (1), along with nine known pterocarpans (2-10) were isolated from the stems of Dalbergia velutina. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines (KB, HeLa S-3, MCF-7, Hep G2, and HT-29). Compound 2 showed potent cytotoxicity against all the five human cancer cell lines with IC₅₀ values in the range of 4.74-8.46 µM. In addition, compounds 1, 3, 4, 5 and 9 showed moderate cytotoxicity against both KB and HeLa S-3 cells with IC₅₀ values in the range of 14.23-29.35 µM.

Keywords: Dalbergia velutina; Velucarpin D; cytotoxicity; pterocarpans.

MeSH terms

Antineoplastic Agents, Phytogenic* / pharmacology
Cell Line, Tumor
Dalbergia*
HeLa Cells
Humans
Molecular Structure
Pterocarpans* / pharmacology

Substances

Antineoplastic Agents, Phytogenic
Pterocarpans