'Nervous' Immunity: Walking the Tightrope

Subhash Kulkarni; Sravya Kurapati; Milena Bogunovic

doi:10.1016/j.it.2020.03.009

'Nervous' Immunity: Walking the Tightrope

Trends Immunol. 2020 May;41(5):359-362. doi: 10.1016/j.it.2020.03.009. Epub 2020 Apr 2.

Authors

Subhash Kulkarni¹, Sravya Kurapati², Milena Bogunovic³

Affiliations

¹ Department of Medicine, Center for Neurogastroenterology, Johns Hopkins University - School of Medicine, Baltimore, MD, USA. Electronic address: skulkar9@jhmi.edu.
² Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA; Department of Microbiology and Immunology, Penn State University College of Medicine, Hershey, PA, USA.
³ Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address: milena.bogunovic@umassmed.edu.

PMID: 32249062
DOI: 10.1016/j.it.2020.03.009

Abstract

There is a major gap in our understanding of how the intestinal immune and nervous systems are integrated to regulate protective adaptations to enteric infections while maintaining tissue homeostasis. Three recent complementary reports published in Cell (2020) provide new mechanistic insights into how this enteric neuro-immune crosstalk may occur.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Homeostasis* / immunology
Humans
Intestinal Diseases* / immunology
Intestinal Diseases* / microbiology
Intestines* / immunology
Nervous System* / immunology