Human airway epithelial cells express a functional IL-5 receptor

Karina T Barretto; Rebecca A Brockman-Schneider; Ine Kuipers; Sarmila Basnet; Yury A Bochkov; Matthew C Altman; Nizar N Jarjour; James E Gern; Stephane Esnault

doi:10.1111/all.14297

Human airway epithelial cells express a functional IL-5 receptor

Allergy. 2020 Aug;75(8):2127-2130. doi: 10.1111/all.14297. Epub 2020 Apr 14.

Authors

Karina T Barretto¹, Rebecca A Brockman-Schneider¹, Ine Kuipers¹, Sarmila Basnet¹, Yury A Bochkov¹, Matthew C Altman^{2

3}, Nizar N Jarjour⁴, James E Gern¹, Stephane Esnault⁴

Affiliations

¹ Department of Pediatrics and Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
² Department of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.
³ Systems Immunology Program, Benaroya Research Institute, Seattle, WA, USA.
⁴ Division of Allergy, Department of Medicine, Pulmonary and Critical Care Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.

Abstract

We found that HBEC expressed the IL-5 receptor, which triggered intracellular signaling and changed gene expression. This data indicate that in addition to targeting eosinophils, IL-5 and anti-IL-5 biologics may have a direct role on AEC.

Keywords: IL-5 receptor; RNA-sequencing; airway epithelial cells; gene expression; intracellular signaling.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Bronchi / diagnostic imaging
Cells, Cultured
Epithelial Cells*
Humans
Interleukin-13*
Receptors, Interleukin-5

Substances

Interleukin-13
Receptors, Interleukin-5

Abstract

Publication types

MeSH terms

Substances

Grants and funding