The Emerging Role of ncRNAs and RNA-Binding Proteins in Mitotic Apparatus Formation

Kei K Ito; Koki Watanabe; Daiju Kitagawa

doi:10.3390/ncrna6010013

The Emerging Role of ncRNAs and RNA-Binding Proteins in Mitotic Apparatus Formation

Noncoding RNA. 2020 Mar 20;6(1):13. doi: 10.3390/ncrna6010013.

Authors

Kei K Ito¹, Koki Watanabe¹, Daiju Kitagawa¹

Affiliation

¹ Department of Physiological Chemistry, Graduate School of Pharmaceutical Science, The University of Tokyo, Bunkyo, Tokyo 113-0033, Japan.

Abstract

Mounting experimental evidence shows that non-coding RNAs (ncRNAs) serve a wide variety of biological functions. Recent studies suggest that a part of ncRNAs are critically important for supporting the structure of subcellular architectures. Here, we summarize the current literature demonstrating the role of ncRNAs and RNA-binding proteins in regulating the assembly of mitotic apparatus, especially focusing on centrosomes, kinetochores, and mitotic spindles.

Keywords: centrosome; kinetochore; mitotic spindle; ncRNA.

Publication types

Review