Snapshot: Trial Types in Precision Medicine

Dane Dickson; Jennifer Johnson; Raymond Bergan; Rebecca Owens; Vivek Subbiah; Razelle Kurzrock

doi:10.1016/j.cell.2020.02.032

Snapshot: Trial Types in Precision Medicine

Cell. 2020 Apr 2;181(1):208-208.e1. doi: 10.1016/j.cell.2020.02.032.

Authors

Dane Dickson¹, Jennifer Johnson², Raymond Bergan³, Rebecca Owens⁴, Vivek Subbiah⁵, Razelle Kurzrock⁶

Affiliations

¹ Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA; Taproot Health, Salt Lake City, UT, USA.
² Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
³ Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
⁴ Taproot Health, Salt Lake City, UT, USA.
⁵ University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁶ Moores Cancer Center, University of California, San Diego, San Diego, CA, USA.

PMID: 32243791
DOI: 10.1016/j.cell.2020.02.032

Abstract

Integrating precision diagnostics into personalized treatments requires understanding how biomarkers relate to clinical outcomes. Various clinical data collection methods exist, each with strengths and weaknesses. Interventional data are high quality but narrowly focused. Real-world data (RWD) provide broader information but with variable quality. Master protocols allow better efficiency in data collection. The master observational trial bridges the gap between interventional and retrospective RWD collection methods. To view this SnapShot, open or download the PDF.

MeSH terms

Clinical Trials as Topic*
Data Collection*
Humans
Precision Medicine*