Abstract
Dipleosporalones A and B (1 and 2), two new [2 + 2] azaphilone dimers, were obtained from a marine-derived Pleosporales sp. fungus. The absolute configurations of 1 and 2 were elucidated by calculations of their ECD spectra. Dipleosporalone A (1) possessed an unprecedented skeleton with an uncommon 6/4/6 ring system. Compounds 1 and 2 showed cytotoxicity about 30-90-fold more potent than that of their monomer pinophilin B.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzopyrans / chemistry
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Benzopyrans / isolation & purification
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Benzopyrans / pharmacology*
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Drug Screening Assays, Antitumor
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Fungi / chemistry*
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Isocoumarins / chemistry
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Isocoumarins / pharmacology
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Molecular Structure
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Pigments, Biological / chemistry
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Pigments, Biological / isolation & purification
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Pigments, Biological / pharmacology*
Substances
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Benzopyrans
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Isocoumarins
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Pigments, Biological
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azaphilone
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pinophilin B