Dipleosporalones A and B, Dimeric Azaphilones from a Marine-Derived Pleosporales sp. Fungus

J Nat Prod. 2020 Apr 24;83(4):1283-1287. doi: 10.1021/acs.jnatprod.0c00132. Epub 2020 Apr 3.

Abstract

Dipleosporalones A and B (1 and 2), two new [2 + 2] azaphilone dimers, were obtained from a marine-derived Pleosporales sp. fungus. The absolute configurations of 1 and 2 were elucidated by calculations of their ECD spectra. Dipleosporalone A (1) possessed an unprecedented skeleton with an uncommon 6/4/6 ring system. Compounds 1 and 2 showed cytotoxicity about 30-90-fold more potent than that of their monomer pinophilin B.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzopyrans / chemistry
  • Benzopyrans / isolation & purification
  • Benzopyrans / pharmacology*
  • Drug Screening Assays, Antitumor
  • Fungi / chemistry*
  • Isocoumarins / chemistry
  • Isocoumarins / pharmacology
  • Molecular Structure
  • Pigments, Biological / chemistry
  • Pigments, Biological / isolation & purification
  • Pigments, Biological / pharmacology*

Substances

  • Benzopyrans
  • Isocoumarins
  • Pigments, Biological
  • azaphilone
  • pinophilin B