Reproducibility, and repeatability of corneal topography measured by Revo NX, Galilei G6 and Casia 2 in normal eyes

PLoS One. 2020 Apr 2;15(4):e0230589. doi: 10.1371/journal.pone.0230589. eCollection 2020.

Abstract

Purpose: To test the repeatability and reproducibility of the topography module in posterior segment spectral domain optical coherence tomography with Revo NX (new device) and to compare keratometry values obtained by a Scheimpflug tomography (Galilei G6) and a swept source OCT (Casia 2).

Methods: In this prospective study, healthy subjects with nonoperated eyes had their central corneal thickness (CCT), anterior and posterior K1/K2 corneal power measured with the new device. Two operators made 6 measurements on the new device to check intraobserver repeatability and reproducibility, and measurement on Casia 2 and Galilei G6. Bland-Altman plots were used to assess the agreement between the devices for each analyzed variable.

Results: 94 eyes (94 patients) were studied. All devices produced significantly different mean CCT, the highest for Galilei 569.13±37.58 μm followed by Casia 545.00 ±36.15 μm and Revo 537.39±35.92 μm. The mean anterior K1 was 43.21 ± 1.37 for Casia 2 43.21 ± 1.55 for Revo NX and 43.19 ± 1.39 for Galilei G6, and the differences were insignificant p = 0.617. The posterior K1 for Revo NX was -5.77 ± 0.25 whereas for Casia 2 it was -5.98±0.22 and for Galilei G6-6.09±0.28 D p< 0.0001. The Revo NX showed intraclass correlation coefficient ranging from 0.975 for the posterior K2 surface, and 0.994 for anterior K1 and 0.998 for CCT.

Conclusions: Revo NX is independent of the user and offers a high level of repeatability for the anterior and posterior cornea. The wide range of differences between the devices suggests they should not be used interchangeably.

MeSH terms

  • Adult
  • Cornea / anatomy & histology*
  • Cornea / physiology*
  • Corneal Pachymetry / methods*
  • Corneal Topography / methods*
  • Female
  • Humans
  • Male
  • Prospective Studies
  • Reproducibility of Results
  • Tomography, Optical Coherence / methods*

Grants and funding

Optopol Technology Ltd. provided the Revo NX equipment with corneal topography module used in this study. AW received a speaker's honorarium form Carl Zeiss and works as a consultant for Carl Zeiss Meditec. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.