Methods: CADTH Horizon Scanning bulletins present an overview of the technology and available evidence. They are not systematic reviews and do not involve critical appraisal, nor do they include a detailed summary of study findings. Therefore, they are not intended to provide recommendations for or against a particular technology.
Literature Search Strategy: A limited literature search was conducted by an information specialist on key resources including PubMed, MEDLINE and Embase via OVID, Scopus, the Cochrane Library, the University of York Centre for Reviews and Dissemination databases, the websites of Canadian and major international health technology agencies, as well as a focused Internet search. The search strategy was comprised of both controlled vocabulary, such as the National Library of Medicine’s MeSH (Medical Subject Headings), and keywords. The main search concept was liquid biopsy. No filters were applied to limit the retrieval by study type. Where possible, retrieval was limited to the human population. The search was also limited to English language documents published between January 1, 2017 and July 9, 2019. Internet links were provided, where available.
Study Selection: One author screened the literature search results and reviewed the full text of all potentially relevant studies. Studies were considered for inclusion if the review included a liquid biopsy that could be utilized for screening or the early detection of cancer. The final selection focused primarily on existing evidence syntheses including literature reviews and/or systematic reviews. Grey literature was included when it provided additional information to that available in the published studies.
Peer Review: A draft version of this bulletin was reviewed by one clinical expert. The manufacturers of the technologies were also given the opportunity to comment on an earlier draft. Feedback received from the manufacturers who submitted input was considered in the final review.
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