FeOOH@Metal-Organic Framework Core-Satellite Nanocomposites for the Serum Metabolic Fingerprinting of Gynecological Cancers

Congcong Pei; Chao Liu; You Wang; Dan Cheng; Rongxin Li; Weikang Shu; Chaoqi Zhang; Wenli Hu; Aihua Jin; Yannan Yang; Jingjing Wan

doi:10.1002/anie.202001135

FeOOH@Metal-Organic Framework Core-Satellite Nanocomposites for the Serum Metabolic Fingerprinting of Gynecological Cancers

Angew Chem Int Ed Engl. 2020 Jun 26;59(27):10831-10835. doi: 10.1002/anie.202001135. Epub 2020 May 7.

Authors

Congcong Pei¹, Chao Liu¹, You Wang^{2

3}, Dan Cheng⁴, Rongxin Li¹, Weikang Shu¹, Chaoqi Zhang¹, Wenli Hu¹, Aihua Jin⁵, Yannan Yang⁴, Jingjing Wan¹

Affiliations

¹ School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.
² Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, Shanghai, 200001, P. R. China.
³ Department of Obstetrics and Gynecology, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200001, P. R. China.
⁴ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
⁵ Institute of Molecular Bioscience, The University of Queensland, St Lucia, Queensland, 4072, Australia.

PMID: 32237260
DOI: 10.1002/anie.202001135

Abstract

High-throughput metabolic analysis is of significance in diagnostics, while tedious sample pretreatment has largely hindered its clinic application. Herein, we designed FeOOH@ZIF-8 composites with enhanced ionization efficiency and size-exclusion effect for laser desorption/ionization mass spectrometry (LDI-MS)-based metabolic diagnosis of gynecological cancers. The FeOOH@ZIF-8-assisted LDI-MS achieved rapid, sensitive, and selective metabolic fingerprints of the native serum without any enrichment or purification. Further analysis of extracted serum metabolic fingerprints successfully discriminated patients with gynecological cancers (GCs) from healthy controls and also differentiated three major subtypes of GCs. Given the low cost, high-throughput, and easy operation, our approach brings a new dimension to disease analysis and classification.

Keywords: diagnostics; gynecological cancers; mass spectrometry; metabolites; metal-organic frameworks.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Female
Ferric Compounds / chemistry*
Genital Neoplasms, Female / blood*
Humans
Metabolome
Metal-Organic Frameworks / chemistry*
Microscopy, Electron / methods
Nanocomposites / chemistry*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
Spectroscopy, Fourier Transform Infrared / methods

Substances

Ferric Compounds
Metal-Organic Frameworks
ferric hydroxide