Acetaminophen-induced hepatotoxicity: different mechanisms of acetaminophen-induced ferroptosis and mitochondrial damage

Arch Toxicol. 2020 Jun;94(6):2255-2257. doi: 10.1007/s00204-020-02722-5. Epub 2020 Mar 31.

Authors

Naoya Yamada¹, Takanori Komada¹, Nobuhiko Ohno², Masafumi Takahashi³

Affiliations

¹ Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
² Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University, Tochigi, Japan.
³ Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. masafumi2@jichi.ac.jp.

PMID: 32236649
DOI: 10.1007/s00204-020-02722-5

No abstract available

Publication types

Letter

MeSH terms

Acetaminophen / toxicity*
Analgesics, Non-Narcotic / toxicity*
Animals
Chemical and Drug Induced Liver Injury / etiology*
Chemical and Drug Induced Liver Injury / metabolism
Chemical and Drug Induced Liver Injury / pathology
Chemical and Drug Induced Liver Injury / prevention & control
Ferroptosis / drug effects*
Free Radical Scavengers / pharmacology
Lipid Peroxidation / drug effects
Liver / drug effects*
Liver / metabolism
Liver / ultrastructure
Mice, Inbred C57BL
Microscopy, Electron, Transmission
Mitochondria, Liver / drug effects*
Mitochondria, Liver / metabolism
Mitochondria, Liver / ultrastructure
Mitochondrial Swelling / drug effects*
Time Factors

Substances

Analgesics, Non-Narcotic
Free Radical Scavengers
Acetaminophen