Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population

Omar Graciano-Machuca; Anabell Alvarado-Navarro; María Guadalupe Ramírez-Dueñas; Delfina Guadalupe Villanueva-Quintero; Erandi Enif Velarde-de la Cruz; Andrea Carolina Machado-Sulbarán; Margarita Montoya-Buelna; Pedro Ernesto Sánchez-Hernández

doi:10.3390/genes11030338

Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population

Genes (Basel). 2020 Mar 22;11(3):338. doi: 10.3390/genes11030338.

Authors

Omar Graciano-Machuca^{1

2}, Anabell Alvarado-Navarro³, María Guadalupe Ramírez-Dueñas⁴, Delfina Guadalupe Villanueva-Quintero^{5

6}, Erandi Enif Velarde-de la Cruz¹, Andrea Carolina Machado-Sulbarán¹, Margarita Montoya-Buelna⁴, Pedro Ernesto Sánchez-Hernández⁴

Affiliations

¹ Doctorate in Biomedical Sciences, Department of Physiology, University Center of Health Sciences (CUCS), University of Guadalajara (UDG), Guadalajara, Jal. 44340, Mexico.
² Laboratory of Biological Systems, Department of Health Sciences, University Center of the Valleys (CUVALLES), UDG, Ameca, Jal. 4660, Mexico.
³ Research Center in Immunology and Dermatology, Department of Physiology, CUCS, UDG, Guadalajara, Jal. 44340, Mexico.
⁴ Laboratory of Immunology, Department of Physiology, CUCS, UDG, Guadalajara, Jal. 44340, Mexico.
⁵ Jalisco Dermatology Institute "Dr. José Barba Rubio", Ministry of Health; Zapopan, Jal. 45190, Mexico.
⁶ Inflammatory Diseases Care Center, Guadalajara, Jal. 44630, Mexico.

Abstract

NK and some T cell functions are regulated by the interaction between KIR and HLA molecules. Several studies have shown an association between activating KIR genes and the development of autoimmune diseases, including psoriasis vulgaris (PsV). Our objective was to determine the association between KIR/HLA genes and genotypes with PsV in the Western mestizo Mexican population. One hundred subjects diagnosed with PsV (SP) and 108 healthy subjects (HS) were genotyped for 14 KIR genes, HLA-Bw4, HLA-C1, and HLA-C2 by PCR-single specific primer (SSP). Positive associations of the KIR3DS1 gene (odds ratio (OR) 1.959, p = 0.021), G11 genotype (OR 19.940, p = 0.008), and KIR3DS1/HLA-A^Bw4 (OR 2.265, p = 0.009) were found with susceptibility to PsV. In contrast, the G1 genotype (OR 0.448, p = 0.031) and KIR3DL1/HLA-Bw4^Ile80 (OR 0.522, p = 0.022) were negatively associated with susceptibility to this disease. These results suggest an implication of the KIR3DS1/HLA-A^Bw4 genotype in PsV pathology.

Keywords: HLA; HLA-Bw4; KIR; KIR3DS1; psoriasis vulgaris.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Alleles
Female
Genotype*
HLA-B Antigens / genetics*
Humans
Male
Mexico
Middle Aged
Psoriasis / genetics*
Receptors, KIR3DS1 / genetics*

Substances

HLA-B Antigens
HLA-Bw4 antigen
KIR3DS1 protein, human
Receptors, KIR3DS1