Euphane- and 19(10 → 9)abeo-euphane-type triterpenoids from Jatropha gossypiifolia

Fitoterapia. 2020 Jun:143:104582. doi: 10.1016/j.fitote.2020.104582. Epub 2020 Mar 28.

Abstract

Four new tetracyclic triterpenoids (1-4) were isolated from the leaves and twigs of Jatropha gossypiifolia. Their structures were elucidated by MS and NMR data analysis, together with the Mo2(OAc)4-induced CD data. Jagabeoeuphols A-C (1-3) are rare 19(10 → 9)abeo-euphane-type triterpenoids possessing a Δ5(10) group and a 7,8-epoxide moiety, and jagoseuphone A (4) is a typical euphane-type triterpenoid. The inhibitory effects of 1-4 on nitric oxide production induced by lipopolysaccharide in RAW264.7 cells were evaluated, and 4 exhibited moderate inhibitory activity with an IC50 value of 20.1 μM.

Keywords: 19(10 → 9)abeo-Euphane triterpenoids; Anti-inflammatory activity; Euphorbiaceae; Jatropha gossypiifolia.

MeSH terms

  • Animals
  • China
  • Jatropha / chemistry*
  • Mice
  • Molecular Structure
  • Nitric Oxide / metabolism
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Leaves / chemistry*
  • RAW 264.7 Cells
  • Triterpenes / chemistry
  • Triterpenes / pharmacology*

Substances

  • Phytochemicals
  • Triterpenes
  • Nitric Oxide