Stability of reaching during standing in stroke

Yosuke Tomita; Nicolas A Turpin; Daniele Piscitelli; Anatol G Feldman; Mindy F Levin

doi:10.1152/jn.00729.2019

Stability of reaching during standing in stroke

J Neurophysiol. 2020 May 1;123(5):1756-1765. doi: 10.1152/jn.00729.2019. Epub 2020 Apr 1.

Authors

Yosuke Tomita¹, Nicolas A Turpin², Daniele Piscitelli^{3

4}, Anatol G Feldman^{4

5}, Mindy F Levin^{3

4}

Affiliations

¹ Department of Physical Therapy, Faculty of Health Care, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan.
² IRISSE (EA 4075), Department of Sport Sciences (STAPS), University of la Réunion; Tampon, France.
³ School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada.
⁴ Centre of the Center for Interdisciplinary Research in Rehabilitation of Greater Montreal, Montreal, Quebec, Canada.
⁵ Département de Neurosciences, Université de Montréal, Montreal, Quebec, Canada.

PMID: 32233891
DOI: 10.1152/jn.00729.2019

Abstract

Reaching from standing requires simultaneous adjustments of focal and postural task elements. We investigated the ability of people with stroke to stabilize the endpoint trajectory while maintaining balance during standing reaches. Nineteen stroke and 11 age-equivalent healthy subjects reached toward a target (n = 30 trials) located beyond arm length from standing. Endpoint and center-of-mass (COM) trajectories were analyzed using the uncontrolled manifold (UCM) approach, with segment angles as elemental variables. A synergy index (SI) represented the normalized difference between segment angle combinations, leading to endpoint or COM trajectory stabilization (V_UCM) and lack of stabilization (in an orthogonal space; V_ORT). A higher SI reflects greater stability. In both groups, the endpoint SI (SI_END) decreased in parallel with endpoint velocity and returned close to baseline at the end of the movement. The range of SI_END was significantly greater in stroke (median: 0.87; QR:0.54) compared with healthy subjects (median: 0.58; QR: 0.33; P = 0.009). In both groups, the lowest SI_END occurred at the endpoint peak velocity, whereas the minimal SI_END of the stroke group (median: 0.51; QR:0.41) was lower than the healthy group (median: 0.25; QR: 0.50; P = 0.033). The COM SI (SI_COM) remained stable in both groups (~0.8). The maintenance of a high SI_COM despite a large reduction of SI_END in stroke subjects suggests that kinematic redundancy was effectively used to stabilize the COM position, but less so for endpoint position stabilization. Both focal and postural task elements should be considered when analyzing whole body reaching deficits in patients with stroke.NEW & NOTEWORTHY Reaching from standing requires simultaneous adjustments of endpoint and center-of-mass (COM) positions. We used uncontrolled manifold analysis to investigate the impact of stroke on the ability to use kinematic redundancy in this task. Our results showed that COM position was stabilized, whereas endpoint trajectory was more variable in stroke than healthy subjects. Enhancing the capacity to meet multiple task goals may be beneficial for motor recovery after stroke.

Keywords: kinematic redundancy; standing reach; stroke; uncontrolled manifold analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Biomechanical Phenomena / physiology*
Female
Humans
Male
Middle Aged
Motor Activity / physiology*
Standing Position*
Stroke / physiopathology*