Enteropathy-associated T-cell Lymphoma (EATL) with intracranial metastasis : a rare and dismal condition

Y Y Chuah; T Tashi; Y Y Lee; T Y Fu; C A Shih

Enteropathy-associated T-cell Lymphoma (EATL) with intracranial metastasis : a rare and dismal condition

Acta Gastroenterol Belg. 2020 Jan-Mar;83(1):77-80.

Authors

Y Y Chuah^{1

2}, T Tashi³, Y Y Lee⁴, T Y Fu⁵, C A Shih^{6

7

8}

Affiliations

¹ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ping Tung Christian Hospital, Ping Tung, Taiwan.
² Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
³ Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
⁴ Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
⁵ Department of Pathology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
⁶ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Antai Medical Care Corporation, Antai Tian-Sheng Memorial Hospital, Pingtung County, Taiwan.
⁷ National Yang-Ming University, Taipei City, Taiwan.
⁸ Department of Nursing, Meiho University, Ping Tung, Taiwan.

PMID: 32233276

Abstract

Background: Enteropathy-associated T-cell lymphoma (EATL) is a rare type of gastrointestinal non-Hodgkin's Lymphoma. EATL with intracranial metastasis is even rarer. We report a case of EATL with intracranial metastasis.

Case presentation: A 36-years old man presented with five weeks history of intractable diarrhea. Colonoscopy was normal, but abdominal computed tomography (CT) scan revealed mural thickening at duodenojejunal junction, and subsequent jejunofiberoscopy showed a circumferential ulceration at the jejunum. Histo-immunopathology confirmed the diagnosis of enteropathyassociated T-cell lymphoma (EATL) type II. His disease course proved to be aggressive and refractory to standard front-line chemotherapy, and eventually progressed through second-line salvage regimen with CNS and intracranial involvement. He died nine months after the initial diagnosis.

Conclusion: EATL with brain metastasis is a very rare occurrence with dismal prognosis.

Keywords: enteropathy-associated T-cell Lymphoma; intracranial metastasis.

Publication types

Case Reports

MeSH terms

Adult
Colonoscopy
Diarrhea
Enteropathy-Associated T-Cell Lymphoma*
Gastrointestinal Neoplasms*
Humans
Male
Prognosis