The long-term outcomes in adolescent and young adult patients with colorectal cancer -A multicenter large-scale cohort study

Yujiro Nakayama; Hiroshi Kobayashi; Hidetaka Kawamura; Rie Matsunaga; Yukitoshi Todate; Yoshinao Takano; Keiichi Takahashi; Shinichi Yamauchi; Kenichi Sugihara; Michitaka Honda

doi:10.7150/jca.36721

The long-term outcomes in adolescent and young adult patients with colorectal cancer -A multicenter large-scale cohort study

J Cancer. 2020 Mar 4;11(11):3180-3185. doi: 10.7150/jca.36721. eCollection 2020.

Authors

Yujiro Nakayama^{1

2}, Hiroshi Kobayashi^{1

2}, Hidetaka Kawamura^{1

2}, Rie Matsunaga^{1

2}, Yukitoshi Todate^{1

2}, Yoshinao Takano², Keiichi Takahashi³, Shinichi Yamauchi⁴, Kenichi Sugihara⁴, Michitaka Honda^{1

2}

Affiliations

¹ Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima.
² Department of Surgery, Southern Tohoku General Hospital, Koriyama.
³ Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo.
⁴ Department of Surgery, Tokyo Medical and Dental University, Tokyo.

Abstract

Introduction: The prognosis of adolescent and young adult (AYA) patients with colorectal cancer (CRC) is still unclear. The aim of this study was to investigate the clinical features and prognosis in AYA patients compared with middle- aged patients. Methods: Participants were identified from a clinical database of the multicenter cohort in Japan. The AYA group was defined as those <40 years of age, whereas the middle-aged group was defined in 10-year ranges around the median age of all patients. The primary outcome was the overall survival (OS), and the secondary outcome was the recurrence-free survival (RFS). Results: A total of 502 patients were enrolled as the AYA group, and 7222 patients between 65 and 74 years of age were identified as the middle-aged group. The OS of colon cancer in stages II and III was significantly better in the AYA group (p = 0.033, 0.006, respectively) than in the middle-aged groups. There were no significant differences in the OS of rectal cancer in stages II and III between the two groups. Conclusion: The prognosis of AYA patients with CRC was the same or better than that in middle-aged patients.

Keywords: Colorectal Neoplasms; adjuvant therapy; adolescent and young adult; middle aged; prognosis.