Amiodarone-Induced Acute Liver Injury

Rajesh Essrani; Shehriyar Mehershahi; Rajesh Kumar Essrani; Shri Jai Kirshan Ravi; Sajeer Bhura; Anuraj Sudhakaran; Muhammad Hossain; Asif Mehmood

doi:10.1159/000506184

Amiodarone-Induced Acute Liver Injury

Case Rep Gastroenterol. 2020 Feb 20;14(1):87-90. doi: 10.1159/000506184. eCollection 2020 Jan-Apr.

Authors

Rajesh Essrani¹, Shehriyar Mehershahi², Rajesh Kumar Essrani², Shri Jai Kirshan Ravi³, Sajeer Bhura⁴, Anuraj Sudhakaran¹, Muhammad Hossain¹, Asif Mehmood¹

Affiliations

¹ Department of Internal Medicine, Geisinger Medical Center, Danville, Pennsylvania, USA.
² General Internal Medicine, Bronx HealthCare System, Bronx, New York, USA.
³ General Internal Medicine, Guthrie Robert Packer Hospital, Sayre, Pennsylvania, USA.
⁴ General Internal Medicine, State University of New York at Buffalo, Buffalo, New York, USA.

Abstract

Amiodarone is a lipophilic structure with a half-life of 25-100 days. Long-term oral amiodarone is associated with photosensitivity, thyroid dysfunction, and pulmonary and hepatic toxicity. Intravenous amiodarone can lead to sweating, heating sensation, nausea, phlebitis at the injection site, and rarely acute hepatitis. This is a compelling case of a 60-year-old male who developed acute liver injury 24-36 h after starting amiodarone. All the possible causes of acute liver injury were ruled out, and his liver enzymes improved after discontinuing amiodarone.

Keywords: Acute liver injury; Amiodarone; Atrial fibrillation; Elevated bilirubin; Lactate dehydrogenase; Shortness of breath.

Publication types

Case Reports