International Consensus Conference for Advanced Breast Cancer, Lisbon 2019: ABC5 Consensus - Assessment by a German Group of Experts

Christoph Thomssen; Diana Lüftner; Michael Untch; Renate Haidinger; Rachel Würstlein; Nadia Harbeck; Doris Augustin; Susanne Briest; Johannes Ettl; Peter A Fasching; Frank Förster; Christian M Kurbacher; Hans-Joachim Lück; Norbert Marschner; Lothar Müller; Volkmar Müller; Lidia Perlova-Griff; Isabel Radke; Eugen Ruckhäberle; Iris Scheffen; Eva Schumacher-Wulf; Moritz Schwoerer; Dieter Steinfeld-Birg; Katja Ziegler-Löhr

doi:10.1159/000505957

International Consensus Conference for Advanced Breast Cancer, Lisbon 2019: ABC5 Consensus - Assessment by a German Group of Experts

Breast Care (Basel). 2020 Feb;15(1):82-95. doi: 10.1159/000505957. Epub 2020 Feb 10.

Authors

Christoph Thomssen¹, Diana Lüftner², Michael Untch³, Renate Haidinger⁴, Rachel Würstlein⁵, Nadia Harbeck⁵, Doris Augustin⁶, Susanne Briest⁷, Johannes Ettl⁸, Peter A Fasching⁹, Frank Förster¹⁰, Christian M Kurbacher¹¹, Hans-Joachim Lück¹², Norbert Marschner¹³, Lothar Müller¹⁴, Volkmar Müller¹⁵, Lidia Perlova-Griff¹⁶, Isabel Radke¹⁷, Eugen Ruckhäberle¹⁸, Iris Scheffen¹⁹, Eva Schumacher-Wulf²⁰, Moritz Schwoerer²¹, Dieter Steinfeld-Birg²², Katja Ziegler-Löhr²³

Affiliations

¹ Klinik und Poliklinik für Gynäkologie, Martin-Luther-Universität Halle-Wittenberg, Halle an der Saale, Germany.
² Medical Department of Hematology, Oncology, and Tumor Immunology, Charité Berlin, Campus Benjamin Franklin, Berlin, Germany.
³ Clinic of Gynecology and Obstetrics, Multidisciplinary Breast Cancer Center, Department of Gynecologic Oncology, HELIOS Klinikum Berlin Buch, Berlin, Germany.
⁴ Brustkrebs Deutschland (German Breast Cancer Association) e.V., Hohenbrunn, Germany.
⁵ Breast Center and Comprehensive Cancer Center (CCC) Munich, Department of Obstetrics and Gynecology, University of Munich (LMU), Munich, Germany.
⁶ Breast Center of Eastern Bavaria, DONAUISAR Hospital of Deggendorf, Deggendorf, Germany.
⁷ Department of Gynecology, University Hospital Leipzig, Leipzig, Germany.
⁸ Department of Gynecology and Obstetrics, University Hospital Rechts der Isar, Munich, Germany.
⁹ Women's Hospital at the University Hospital Erlangen, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.
¹⁰ Practice for Gynecology and Obstetrics, Gynecological Oncology and Palliative Care, Poliklinik gGmbH, Chemnitz, Germany.
¹¹ Practice - Gynecology I (Gynecologic Oncology), Gynecologic Center Bonn-Friedensplatz, Bonn, Germany.
¹² Practice for Hemato-Oncology, Hannover, Germany.
¹³ Joint Practice for Interdisciplinary Oncology and Hematology, Freiburg, Germany.
¹⁴ Oncology Specialist Practice of Leer-Emden-Papenburg, Leer-Emden-Papenburg, Germany.
¹⁵ Department of Gynecology, University Hospital, Hamburg-Eppendorf, Germany.
¹⁶ Gynecological Oncology of Wilmersdorf, Treatment Center II of the St. Gertrude Hospital, Berlin, Germany.
¹⁷ Breast Center, University Hospital of Münster, Münster, Germany.
¹⁸ Department of Obstetrics and Gynecology, University Hospital Düsseldorf, Düsseldorf, Germany.
¹⁹ Breast Center at St. Elisabeth Hospital, Cologne, Germany.
²⁰ Mamma Mia! Breast Cancer Magazine, Kronberg, Germany.
²¹ Department of Gynecology, Hospital Fürstenfeldbruck, Fürstenfeldbruck, Germany.
²² Practice for Gynecological Oncology, Augsburg, Germany.
²³ Practice for Gynecological Oncology, Cologne, Germany.

Abstract

The 5th International Consensus Conference for Advanced Breast Cancer (ABC5) took place on November 14-16, 2019, in Lisbon, Portugal. Its aim is to standardize the treatment of advanced breast cancer based on the available evidence and to ensure that all breast cancer patients worldwide receive adequate treatment and access to new therapies. This year, the conference focused on developments and study results in the treatment of patients with hormone receptor-positive/HER2-negative breast cancer as well as precision medicine. As in previous years, patient advocates from around the world were integrated into the ABC conference and had seats on the ABC consensus panel. In the present paper, a working group of German breast cancer experts comments on the results of the on-site ABC5 consensus votes by ABC panelists regarding their applicability for routine treatment in Germany. These comments take the recommendations of the Breast Committee of the Gynecological Oncology Working Group (Arbeitsgemeinschaft Gynäkologische Onkologie; AGO) into account. The report and assessment presented here pertain to the preliminary results of the ABC5 consensus. The final version of the statements will be published in Annals of Oncology and The Breast.

Keywords: 5th International Consensus Conference for Advanced Breast Cancer; Advanced breast cancer; BRCA-associated advanced breast cancer; Hormone receptor-positive and HER2-positive advanced breast cancer; Personalized medicine; Triple-negative advanced breast cancer.