Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-KIT

Exp Biol Med (Maywood). 2020 Apr;245(8):711-719. doi: 10.1177/1535370220915826. Epub 2020 Mar 29.

Abstract

Ovarian aging is becoming a more important issue in terms of fertility preservation and infertility treatment. Serum anti-Mullerian hormone (AMH) level and antral follicle count (AFC) are being practically used as markers of ovarian aging as well as ovarian reserve in human. However, these factors have some drawbacks in assessing ovarian aging and reserve. Therefore, the identification of ovarian expressions of BMP15, GDF9, and C-KIT according to female could be applied as a potent predictor of ovarian aging. This work provides new information on the development of diagnosis and treatment strategy of age-related fertility decline and premature ovarian insufficiency.

Keywords: BMP15; C-KIT; GDF9; Ovarian aging; biomarkers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / metabolism*
  • Animals
  • Bone Morphogenetic Protein 15 / genetics*
  • Bone Morphogenetic Protein 15 / metabolism
  • Female
  • Growth Differentiation Factor 9 / genetics*
  • Growth Differentiation Factor 9 / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Ovary / growth & development
  • Ovary / metabolism*
  • Proto-Oncogene Proteins c-kit / genetics*
  • Proto-Oncogene Proteins c-kit / metabolism

Substances

  • Bmp15 protein, mouse
  • Bone Morphogenetic Protein 15
  • Gdf9 protein, mouse
  • Growth Differentiation Factor 9
  • Proto-Oncogene Proteins c-kit