Preparation and separation of epothilones with anticancer activity

Rong Long; Wenjian Yang; Gangliang Huang

doi:10.1111/cbdd.13687

Preparation and separation of epothilones with anticancer activity

Chem Biol Drug Des. 2020 Aug;96(2):785-789. doi: 10.1111/cbdd.13687. Epub 2020 Apr 12.

Authors

Rong Long¹, Wenjian Yang¹, Gangliang Huang¹

Affiliation

¹ Active Carbohydrate Research Institute, Chongqing Key Laboratory of Green Synthesis and Application, College of Chemistry, Chongqing Normal University, Chongqing, China.

PMID: 32220102
DOI: 10.1111/cbdd.13687

Abstract

Epothilone is a kind of macrolide compound, which has anticancer activity and strong inhibitory effect on breast cancer and rectal cancer cells. Herein, the chemical and biological synthesis of epothilones and how to improve fermentation yield and separation methods were summarized and discussed.

Keywords: epothilones; separation; synthesis; yield.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Apoptosis / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Ceramics / chemistry
Drug Screening Assays, Antitumor
Epothilones / biosynthesis*
Epothilones / chemical synthesis*
Epothilones / isolation & purification*
Epothilones / pharmacology
Fermentation
Glycosylation
Humans
Mutation
Porosity
Secondary Metabolism
Streptomyces / genetics
Streptomyces / metabolism
Structure-Activity Relationship
Surface Properties

Substances

Antineoplastic Agents
Epothilones