Graphene-based nanomaterials in biosystems

Na Lu; Liqian Wang; Min Lv; Zisheng Tang; Chunhai Fan

doi:10.1007/s12274-018-2209-3

Graphene-based nanomaterials in biosystems

Nano Res. 2019;12(2):247-264. doi: 10.1007/s12274-018-2209-3. Epub 2018 Oct 15.

Authors

Na Lu¹, Liqian Wang², Min Lv², Zisheng Tang^{3

4

5}, Chunhai Fan^{2

6}

Affiliations

¹ 1School of Materials Engineering, Shanghai University of Engineering Science, Shanghai, 201620 China.
² 2Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 China.
³ 3Department of Endodontics, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011 China.
⁴ National Clinical Research Center of Oral Diseases, Shanghai, 200011 China.
⁵ 5Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, 200011 China.
⁶ 6School of Chemistry and Chemical Engineering, and Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240 China.

Abstract

Graphene-based nanomaterials have emerged as a novel type of materials with exceptional physicochemical properties and numerous applications in various areas. In this review, we summarize recent advances in studying interactions between graphene and biosystems. We first provide a brief introduction on graphene and its derivatives, and then discuss on the toxicology and biocompatibility of graphene, including the extracellular interactions between graphene and biomacromolecules, cellular studies of graphene, and in vivo toxicological effects. Next, we focus on various graphene-based practical applications in antibacterial materials, wound addressing, drug delivery, and water purification. We finally present perspectives on challenges and future developments in these exciting fields.

Keywords: applications; biomacromolecules; cells; graphene-based nanomaterials; living entities; toxicology and biocompatibility.

Publication types

Review