Review of Clay-Drug Hybrid Materials for Biomedical Applications: Administration Routes

Myung Hun Kim; Goeun Choi; Ahmed Elzatahry; Ajayan Vinu; Young Bin Choy; Jin-Ho Choy

doi:10.1346/CCMN.2016.0640204

Review of Clay-Drug Hybrid Materials for Biomedical Applications: Administration Routes

Clays Clay Miner. 2016;64(2):115-130. doi: 10.1346/CCMN.2016.0640204. Epub 2016 Apr 1.

Authors

Myung Hun Kim^{1

2}, Goeun Choi¹, Ahmed Elzatahry^{3

4}, Ajayan Vinu⁵, Young Bin Choy^{2

6}, Jin-Ho Choy^{1

5}

Affiliations

¹ 14Center for Intelligent Nano-Bio Materials (CINBM), Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 03760 Republic of Korea.
² 24Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, 08826 Republic of Korea.
³ 34Department of Chemistry, King Saud University, 2455, Riyadh 11451, Kingdom of Saudi Arabia.
⁴ 44Materials Science and Technology Program, College of Arts and Science, Qatar University, 2713 Doha, Qatar.
⁵ 54Future Industries Institute, University of South Australia, Mawson Lakes, SA Australia.
⁶ 64Department of Biomedical Engineering, College of Medicine and Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, 03080 Republic of Korea.

Abstract

Focus here is placed on the pharmaceutical and biomedical applications of novel clay-drug hybrid materials categorized by methods of administration. Clay minerals have been used for many years as pharmaceutical and medicinal ingredients for therapeutic purposes. A number of studies have attempted to explore clay-drug hybrid materials for biomedical applications with desired functions, such as sustained release, increased solubility, enhanced adsorption, mucoadhesion, biocompatibility, targeting, etc. The present review attempts not only to summarize the state-of-the-art of clay-drug hybrid materials and their advantages, depending on the methods of administration, but also to deal with challenges and future perspectives of clay mineral-based hybrids for biomedical applications.

Keywords: Administration Methods; Biocompatibility; Biomedical Applications; Clay-drug Hybrid; Mucoadhesion; Pharmaceutical Applications; Sustained Release; Targeting.