Effects of Hoodia Parviflora on satiety, abdominal obesity and weight in a group of overweight subjects: a randomized, blinded, placebo-controlled trial

Minerva Gastroenterol Dietol. 2020 Sep;66(3):211-218. doi: 10.23736/S1121-421X.20.02669-0. Epub 2020 Mar 24.

Abstract

Background: This study aimed to assess the effects of supplementation with Hoodia Parviflora (H. Parviflora) at 9 mg+200 mg of fructo-oligosaccharides on weight loss, body composition, hydration and satiety parameters.

Methods: A randomized blinded controlled trial was conducted in a sample of 30 overweight and obese patients (5 males and 25 females). Patients were randomly assigned in 2 groups: the intervention group, which received H. Parviflora twice a day for 4 weeks and the control group, which received a placebo.

Results: After a 4-week follow-up period, the study results showed an improvement of Δ=-1.632 kg (Confidence Interval [CI]95% -2.545; -0.719) and a statistically significant decrease in waist circumference (WC) compared with the placebo group -2.080 cm ([CI]95% -4.082; -0.078). The visual analogue scale reported an improvement of satiety sensation after day 5 (P=0.001).

Conclusions: This study shows for the first time the simultaneous effect of H. Parviflora on weight loss, decreasing satiety, and improving fat mass, in particular Visceral Adipose Tissue (VAT).

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Female
  • Hoodia*
  • Humans
  • Male
  • Middle Aged
  • Obesity, Abdominal / drug therapy*
  • Overweight / drug therapy*
  • Phytotherapy*
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use*
  • Satiation / drug effects*
  • Single-Blind Method
  • Treatment Outcome
  • Weight Loss / drug effects*

Substances

  • Plant Extracts