Organotin polyamine ethers containing acyclovir in their backbone were synthesized in moderate to high yield employing the aqueous interfacial polycondensation system. The products are high molecular weight polymers. Infrared spectroscopy of the products shows new bands characteristic of the formation of Sn-N and Sn-O bonds consistent with the proposed structure. MALDI-TOF MS below 2000 Da shows the presence of organotin and acyclovir units containing these two moieties. The products show moderate inhibition of a number of cancer cell lines and exhibit the ability to inhibit a number of viruses, particularly the herpes simplex virus-1 and varicella zoster virus that are responsible for herpes, chicken pox and shingles.
Keywords: 143 cells; BS-C-1 cells; HSV-1 viruses; L929 cells; MALDI-TOF MS; Organotin polymers; VZV virus; acyclovir; anticancer drugs; bioterrorism; chicken pox; herpes; herpes simplex virus; interfacial polymerization; reovirus ST3; shingles; small pox; vaccinia WR virus; varicella zoster virus; vero cells; viruses.
© Springer Science+Business Media, Inc. 2006.