Descriptors of 2D-dynamic graphs as a classification tool of DNA sequences

Piotr Wąż; Dorota Bielińska-Wąż; Ashesh Nandy

doi:10.1007/s10910-013-0249-1

Descriptors of 2D-dynamic graphs as a classification tool of DNA sequences

J Math Chem. 2014;52(1):132-140. doi: 10.1007/s10910-013-0249-1. Epub 2013 Sep 3.

Authors

Piotr Wąż¹, Dorota Bielińska-Wąż², Ashesh Nandy³

Affiliations

¹ 1Department of Nuclear Medicine, Medical University of Gdańsk, Tuwima 15, 80-210 Gdańsk, Poland.
² 2Department of Radiological Informatics and Statistics, Medical University of Gdańsk, Tuwima 15, 80-210 Gdańsk, Poland.
³ Centre for Interdisciplinary Research and Education, 404B Jodhpur Park, Kolkata, 700068 India.

Abstract

A new tool of the classification of DNA sequences is introduced. The method is based on 2D-dynamic graphs and their descriptors. Using the descriptors created by centers of masses, moments of inertia, angles between the x axis and the principal axis of inertia of the 2D-dynamic graphs one can obtain classification diagrams in which similar sequences are clustered in separated areas.

Keywords: Center of mass; Descriptors; Graphical representations of DNA sequences; Moments of inertia; Similarity/dissimilarity analysis of DNA sequences.