Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives

Samir Y Abbas; Awatef A Farag; Yousry A Ammar; Abeer A Atrees; Aly F Mohamed; Ahmed A El-Henawy

doi:10.1007/s00706-013-1034-3

Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives

Monatsh Chem. 2013;144(11):1725-1733. doi: 10.1007/s00706-013-1034-3. Epub 2013 Jul 12.

Authors

Samir Y Abbas¹, Awatef A Farag^{2

3}, Yousry A Ammar^{4

3}, Abeer A Atrees², Aly F Mohamed⁵, Ahmed A El-Henawy³

Affiliations

¹ 1Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt.
² 2Chemistry Department, Faculty of Education, Taif University, Taif, Saudi Arabia.
³ 3Chemistry Department, Faculty of Science, Al-Azhar University (Girls), Cairo, Egypt.
⁴ 4Chemistry Department, Faculty of Science, King Khaled University, Abha, Saudi Arabia.
⁵ 5Applied Research Sector, VACSERA, Cairo, Egypt.

Abstract

Abstract: New series of Schiff's bases, hydrazones, thiosemicarbazones, thiazoles, and thiocarbohydrazones of 5-fluoroisatin were synthesized by the reaction of 5-fluoroisatin with primary amines, hydrazine hydrate, and thiocarbohydrazides. Thiosemicarbazones were prepared by reacting hydrazone derivatives with isothiocyanates. Upon treatment of thiosemicarbazone derivatives with chloroacetone, the thiazole derivatives were obtained. Some of the prepared compounds exhibited antiviral activity.

Keywords: Carbonyl compounds; Schiff bases; Thiazoles; Thiosemicarbazones.