Synthesis and Biological Activity of Several Modified 5 α-Androstanolone Derivatives

N Sh Nadaraia; N N Barbakadze; M L Kakhabrishvili; B Sylla; A Pichette; U S Makhmudov

doi:10.1007/s10600-018-2330-2

Synthesis and Biological Activity of Several Modified 5 α-Androstanolone Derivatives

Chem Nat Compd. 2018;54(2):310-314. doi: 10.1007/s10600-018-2330-2. Epub 2018 Apr 14.

Authors

N Sh Nadaraia¹, N N Barbakadze¹, M L Kakhabrishvili¹, B Sylla², A Pichette², U S Makhmudov³

Affiliations

¹ 1I. Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University, 0159 Tbilisi, Georgia.
² LASEVE, Universite Quebec a Chicoutimi, Chicoutimi, QC G7H 2B1 Canada.
³ 3S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.

Abstract

Several new N-containing epiandrosterone derivatives modified by phenylacetic acid chloride were synthesized for biological activity studies. Compounds with antiviral activity were discovered among them and 3β-hydroxy-1'-aryl-3'-methyl-5'-androstano[17,16-d]pyrazolines prepared by us earlier.

Keywords: antiviral activity; epiandrosterone; hydrazones; modification; phenylacetic acid; pyrazolines.