Privileged heterocycles: bioactivity and synthesis of 1,9-diazaspiro[5.5]undecane-containing compounds

Daniel Blanco-Ania; Rik Heus; Floris P J T Rutjes

doi:10.1007/s10593-017-2133-6

Privileged heterocycles: bioactivity and synthesis of 1,9-diazaspiro[5.5]undecane-containing compounds

Chem Heterocycl Compd (N Y). 2017;53(8):827-845. doi: 10.1007/s10593-017-2133-6. Epub 2017 Oct 5.

Authors

Daniel Blanco-Ania¹, Rik Heus¹, Floris P J T Rutjes¹

Affiliation

¹ Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6526 AJ Nijmegen, the Netherlands.

Abstract

This review discusses the biological activity and synthesis of 1,9-diazaspiro[5.5]undecanes, including those ring-fused with arenes and heteroarenes and/or containing a carbonyl group at position 2. These compounds could be used for the treatment of obesity, pain, as well as various immune system, cell signaling, cardiovascular, and psychotic disorders.

Keywords: 1,9-diazaspiro[5.5]undecan-2-one; 1,9-diazaspiro[5.5]undecane; obesity; pain treatment; spiro dipiperidines.