Evolving therapeutic goals in Crohn's disease management

United European Gastroenterol J. 2020 Mar;8(2):133-139. doi: 10.1177/2050640619887316. Epub 2019 Nov 4.

Abstract

The main objectives in Crohn's disease are to avoid disease complications and preserve the patient's quality of life. Early disease control and close monitoring with specific targets to reach might be the only way to change the disease course. In two decades, we have moved from clinical response to full remission (clinical and endoscopic remission) requiring a tight monitoring of both symptoms and objective signs of inflammation. This review summarizes the concepts of tight control and treat-to-target and their potential for disease modification.

Keywords: Crohn's disease; Tight control; treat-to-target.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adalimumab / therapeutic use
  • Adult
  • Anti-Inflammatory Agents / therapeutic use
  • Biomarkers / analysis
  • Budesonide / therapeutic use
  • Colonoscopy / standards
  • Crohn Disease / diagnosis
  • Crohn Disease / immunology
  • Crohn Disease / pathology
  • Crohn Disease / therapy*
  • Disease Management*
  • Disease Progression
  • Female
  • Gastroenterology / methods
  • Gastroenterology / standards*
  • Goals*
  • Humans
  • Inflammation Mediators / analysis
  • Intestinal Mucosa / diagnostic imaging
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / pathology
  • Intestinal Mucosa / surgery
  • Magnetic Resonance Imaging
  • Patient Reported Outcome Measures
  • Practice Guidelines as Topic*
  • Prognosis
  • Quality of Life
  • Remission Induction / methods
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents
  • Biomarkers
  • Inflammation Mediators
  • Budesonide
  • Adalimumab