An amelanotic choroidal melanoma arising in a young man with tattoo-associated sarcoidosis

Sean T Berkowitz; Anderson L Brock; David A Reichstein

doi:10.1016/j.ajoc.2020.100655

An amelanotic choroidal melanoma arising in a young man with tattoo-associated sarcoidosis

Am J Ophthalmol Case Rep. 2020 Mar 7:18:100655. doi: 10.1016/j.ajoc.2020.100655. eCollection 2020 Jun.

Authors

Sean T Berkowitz¹, Anderson L Brock², David A Reichstein²

Affiliations

¹ Vanderbilt University School of Medicine, USA.
² Tennessee Retina, PC, Nashville, TN, USA.

Abstract

Purpose: To describe a patient with an amelanotic choroidal melanoma, originally misdiagnosed as a choroidal granuloma, following his systemic diagnosis of tattoo-associated sarcoidosis.

Observations: The amelanotic choroidal tumor, suspected to be a granuloma, failed initial steroid treatment. Full-thickness chorioretinal biopsy demonstrated histologic presence of uveal melanoma and tumor genetics via GEP analysis demonstrated a PRAME negative, Class 1A lesion. The amelanotic choroidal melanoma was treated successfully with I-125 plaque brachytherapy.

Conclusion and importance: Despite a systemic diagnosis which predisposes a patient to uveal granuloma, amelanotic choroidal melanomas can still occur and should be considered. The association of uveal melanoma and sarcoidosis remains rare and of unclear significance.

Keywords: Eye; Sarcoidosis; Tumor; Uveal melanoma.

Publication types

Case Reports