Molecular perspective and anticancer activity of medicinal plants

Anis Ahamed; A Panneerselvam; Abdullah Alaklabi; Ibrahim A Arif; V Ambikapathy; N Thajuddin

doi:10.1016/j.sjbs.2019.11.043

Molecular perspective and anticancer activity of medicinal plants

Saudi J Biol Sci. 2020 Feb;27(2):666-675. doi: 10.1016/j.sjbs.2019.11.043. Epub 2019 Dec 17.

Authors

Anis Ahamed^{1

2}, A Panneerselvam², Abdullah Alaklabi³, Ibrahim A Arif¹, V Ambikapathy², N Thajuddin⁴

Affiliations

¹ Prince Sultan Research Chair for Environment and Wildlife, Department of Botany and Microbiology, College of Sciences, King Saud University (KSU), Riyadh, Saudi Arabia.
² Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi, Affiliated to Bharathidasan University, Thanjavur, India.
³ Faculty of Science, Department of Biological Science, University of Jeddah, Jeddah, Saudi Arabia.
⁴ Department of Microbiology, Bharathidasan University, Tiruchirappalli, India.

Abstract

To evaluate phytochemical constituents from the methanolic extracts of medicinal plants Aloe castellorum and Aloe pseudorubroviolacea. The cytotoxic activity of Aloe castellorum and Aloe pseudorubroviolacea leaf extracts against Human colon cancer cell line (HCT-116) was also assessed. The two medicinal plant extracts having significant cytotoxic activity, meanwhile the methanolic extract of Aloe castellorum shows higher cytotoxic activity than Aloe pseudorubroviolacea extract. The Aloe castellorum shows remarkable activity against respective cell line than control. The characteristic chemical constituents of Aloe castellorum and Aloe pseudorubroviolacea leaf extracts were recognized from Gas chromatography and Mass spectrometry (GC-MS) technique. The molecular docking studies also support the cytotoxic activity.

Keywords: Aloe castellorum; Aloe pseudorubroviolacea; Anticancer activity; Molecular docking.