Non-coding RNAs: Key regulators of aerobic glycolysis in breast cancer

Min Xia; Shujun Feng; Zuyao Chen; Gebo Wen; Xuyu Zu; Jing Zhong

doi:10.1016/j.lfs.2020.117579

Non-coding RNAs: Key regulators of aerobic glycolysis in breast cancer

Life Sci. 2020 Jun 1:250:117579. doi: 10.1016/j.lfs.2020.117579. Epub 2020 Mar 21.

Authors

Min Xia¹, Shujun Feng², Zuyao Chen³, Gebo Wen¹, Xuyu Zu⁴, Jing Zhong⁵

Affiliations

¹ Institute of Clinical Medicine, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, PR China; Department of Metabolism and Endocrinology, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, PR China.
² Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, University of South China.
³ Institute of Clinical Medicine, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, PR China.
⁴ Institute of Clinical Medicine, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, PR China; Cancer Research Institute, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, PR China. Electronic address: zuxuyu0108@hotmail.com.
⁵ Institute of Clinical Medicine, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, PR China; Cancer Research Institute, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, PR China. Electronic address: zhongjing2002@usc.edu.cn.

PMID: 32209425
DOI: 10.1016/j.lfs.2020.117579

Abstract

Although extensive research progress has been made in breast cancer in recent years, yet the morbidity and mortality rates of breast cancer are rising, making it the major disease that endangers women's health. Energy metabolism reprogramming is featured by a state termed "aerobic glycolysis" or the Warburg effect that glycolysis is preferred even under aerobic conditions in neoplastic diseases. Widely acknowledged as an emerging hallmark in cancers, this metabolic switch shows a sophisticated role in the pathogenesis of breast cancer. The regulating effect of non-coding RNAs (ncRNAs) composed of microRNAs, long non-coding RNAs and circular RNAs is closely related to the glycolysis in breast cancer. Therefore, understand the mechanisms of ncRNAs of aerobic glycolysis in breast cancer may provide new strategy for the disease.

Keywords: Aerobic glycolysis; Breast cancer; Non-coding RNAs (ncRNAs); Warburg effect.

Publication types

Review

MeSH terms

Aerobiosis
Breast Neoplasms / metabolism*
Cell Line, Tumor
Female
Gene Expression Regulation, Neoplastic*
Genes, Tumor Suppressor
Glucose / metabolism
Glycolysis*
Humans
MicroRNAs / metabolism
Neoplasms / metabolism
Oncogenes
RNA, Circular / metabolism
RNA, Long Noncoding / metabolism
RNA, Untranslated / metabolism*
Signal Transduction

Substances

MicroRNAs
RNA, Circular
RNA, Long Noncoding
RNA, Untranslated
Glucose