Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT

Xianfu Meng; Boyu Zhang; Yan Yi; Hui Cheng; Baoming Wang; Yanyan Liu; Teng Gong; Wei Yang; Yefeng Yao; He Wang; Wenbo Bu

doi:10.1021/acs.nanolett.9b05267

Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT

Nano Lett. 2020 Apr 8;20(4):2522-2529. doi: 10.1021/acs.nanolett.9b05267. Epub 2020 Mar 30.

Authors

Xianfu Meng¹, Boyu Zhang², Yan Yi¹, Hui Cheng¹, Baoming Wang³, Yanyan Liu¹, Teng Gong¹, Wei Yang¹, Yefeng Yao⁴, He Wang^{2

5}, Wenbo Bu^{1

6}

Affiliations

¹ Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
² Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China.
³ School of Life Sciences, University of Technology Sydney, Sydney, NSW 2007, Australia.
⁴ Department of Physics and Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, China.
⁵ Human Phenome Institute, Fudan University, Shanghai 200433, China.
⁶ State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.

PMID: 32208714
DOI: 10.1021/acs.nanolett.9b05267

Abstract

Photothermal therapy (PTT) is an efficient approach for cancer treatment. However, accurately monitoring the spatial distribution of photothermal transducing agents (PTAs) and mapping the real-time temperature change in tumor and peritumoral normal tissue remain a huge challenge. Here, we propose an innovative strategy to integrate T₁-MRI for precisely tracking PTAs with magnetic resonance temperature imaging (MRTI) for real-time monitoring temperature change in vivo during PTT. NaBiF₄: Gd@PDA@PEG nanomaterials were synthesized with favorable T₁-weighted performance to target tumor and localize PTAs. The extremely weak susceptibility (1.04 × 10^-6 emu g^-1 Oe^1-) of NaBiF₄: Gd@PDA@PEG interferes with the local phase marginally, which maintains the capability of MRTI to dynamically record real-time temperature change in tumor and peritumoral normal tissue. The time resolution is 19 s per frame, and the detection precision of temperature change is approximately 0.1 K. The approach achieving PTT guided by multimode MRI holds significant potential for the clinical application.

Keywords: T1-MRI; magnetic resonance temperature imaging (MRTI); photothermal therapy (PTT); temperature monitoring.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bismuth / analysis
Gadolinium / analysis
Magnetic Resonance Imaging / methods*
Mice
Nanostructures / analysis*
Neoplasms / diagnostic imaging
Neoplasms / therapy*
Photothermal Therapy / methods*
Sodium Fluoride / analysis
Temperature
Thermography / methods*

Substances

Sodium Fluoride
Gadolinium
Bismuth