chiro-Inositol Derivatives from Chisocheton paniculatus Showing Inhibition of Nitric Oxide Production

J Nat Prod. 2020 Apr 24;83(4):1201-1206. doi: 10.1021/acs.jnatprod.9b01239. Epub 2020 Mar 25.

Abstract

Six new chiro-inositol derivatives (1-6) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam. Their chemical structures were elucidated by 1D and 2D NMR and HRESIMS analyses. All isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in the RAW 264.7 macrophage cell line. Compound 4 exhibited potent inhibitory activity for NO production with an IC50 value of 7.1 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Inositol / chemistry*
  • Lipopolysaccharides / chemistry
  • Lipopolysaccharides / pharmacology*
  • Macrophages / metabolism
  • Meliaceae / chemistry
  • Mice
  • Molecular Structure
  • Nitric Oxide / biosynthesis*
  • Nitric Oxide / chemistry
  • Plant Leaves / chemistry*
  • RAW 264.7 Cells
  • Vietnam

Substances

  • Lipopolysaccharides
  • Nitric Oxide
  • Inositol