Odoriferous Therapy: A Review Identifying Essential Oils against Pathogens of the Respiratory Tract

Chem Biodivers. 2020 Jun;17(6):e2000062. doi: 10.1002/cbdv.202000062. Epub 2020 Jun 16.

Abstract

This review explores the body of scientific information available on the antimicrobial properties of essential oils against pathogens responsible for respiratory infections and critically compares this to what is recommended in the Layman's aroma-therapeutic literature. Essential oils are predominantly indicated for the treatment of respiratory infections caused by bacteria or viruses (total 79.0 %), the efficacy of which has not been confirmed through clinical trials. When used in combination, they are often blended for presumed holistic synergistic effects. Of the essential oils recommended, all show some degree of antioxidant activity, 50.0 % demonstrate anti-inflammatory effects and 83.3 % of the essential oils showed antihistaminic activity. Of the essential oils reviewed, 43.8 % are considered non-toxic while the remaining essential oils are considered slightly to moderately toxic (43.7 %) or the toxicity is unknown (12.5 %). Recommendations are made for further research into essential oil combinations.

Keywords: antimicrobial properties; aromatherapy; combination; drug discovery; essential oils; natural products; respiratory tract.

Publication types

  • Review

MeSH terms

  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology
  • Anti-Infective Agents / therapeutic use
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / therapeutic use
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use
  • Bacteria / drug effects*
  • Fungi / drug effects*
  • Humans
  • Oils, Volatile / chemistry
  • Oils, Volatile / pharmacology*
  • Oils, Volatile / therapeutic use
  • Plants, Medicinal / chemistry
  • Plants, Medicinal / metabolism
  • Respiratory Tract Infections / drug therapy
  • Respiratory Tract Infections / microbiology
  • Respiratory Tract Infections / pathology*
  • Viruses / drug effects*

Substances

  • Anti-Infective Agents
  • Anti-Inflammatory Agents
  • Antiviral Agents
  • Oils, Volatile