The retina revolution: signaling pathway therapies, genetic therapies, mitochondrial therapies, artificial intelligence

Curr Opin Ophthalmol. 2020 May;31(3):207-214. doi: 10.1097/ICU.0000000000000656.

Abstract

Purpose of review: The aim of this article is to review and discuss the history, current state, and future implications of promising biomedical offerings in the field of retina.

Recent findings: The technologies discussed are some of the more recent promising biomedical developments within the field of retina. There is a US Food and Drug Administration-approved gene therapy product and artificial intelligence device for retina, with many other offerings in the pipeline.

Summary: Signaling pathway therapies, genetic therapies, mitochondrial therapies, and artificial intelligence have shaped retina care as we know it and are poised to further impact the future of retina care. Retina specialists have the privilege and responsibility of shaping this future for the visual health of current and future generations.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use
  • Artificial Intelligence*
  • Genetic Therapy*
  • Humans
  • Mitochondria / drug effects*
  • Oligopeptides / therapeutic use
  • Retinal Diseases / therapy*
  • Signal Transduction / drug effects*
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors

Substances

  • Angiogenesis Inhibitors
  • Oligopeptides
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide